Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, and preparation method and use thereof

ABSTRACT

A Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, comprising first type of medicinal materials and second type of medicinal materials. The first type of medicinal materials include Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, Radix Angelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii, Radix Linderae, Glycyrrhizae, Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei. The second type of medicinal materials is one, two or three selected from the group cosisting of  Zingiber Officinale, Olibanum  and  Myrrha.  The preparation method for the Chinese herbal medicine composition comprises the following steps: adding the first type of medicinal materials and the second type of medicinal materials into a container with organic solvent, heating, filtering, and then condensing the filtrate into an extratum.

FIELD OF THE INVENTION

The invention relates a Chinese herbal medicine composition used forantiinflammation, detumescence and acesodyne; and more specifically, toa Chinese herbal medicine extractive used for antiinflammation,detumescence and acesodyne and a preparation method and use thereof

BACKGROUND OF THE INVENTION

The life of modern people has become more and more stress and busy, theyhave not much time to do exercises, and they always stand or sit, thusmodern people often have many civilization diseases, such as nerve orbones and muscles inflammation, muscle ache and so on. If lackingtreatment, the result is that vicious circle forms, qi and blood can notcirculate smoothly.

From the earliest times, it has been several thousand years sinceChinese people used Chinese herbal medicine to treat diseases. All thetime, they apply the method of consolidating the constitution andresisting the pathogen to cure foreign diseases, and solve the intrinsicinflammation or ache, which make Chinese herbal medicine continue today.

At present, workers in Chinese herbal medicine industry still developChinese herbal medicine patch. The Chinese herbal medicine patch isconvenient for external use, what is needed is only to place Chineseherbal medicine patch on the skin of area which suffers from pain ordiscomfort, and efficacy can work by making the ingredients in Chineseherbal medicine patch penetrate into the skin of body.

Panchrest plaster has been used for curing the symptoms of body ache anddiscomfort etc. since ancient times, therefore efficacy has beenconfirmed for a long time, the formula is composed of 17 kinds ofmedicinal materials, such as Radix Aconiti, Momordica Cochinchinensis,Radix Aconiti Kusnezoffii, Radix Rehmanniae, Ampelopsis Japonica,Rhizoma Bletillae, Cortex Cinnamon, Radix Angelicae Formosanae, RadixAngelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Notopterygii, RadixSophorae Flavescentis, Radix Linderae, Glycyrrhiza, Radix AngelicaePubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei. However, a partof medicinal materials in the above formula, such as Radix Aconiti,Momordica Cochinchinensis, Radix Aconiti Kusnezoffii, have been verifiedto be toxic and have dermal irritation, which may cause skin discomfortafter using, as showed in Table 1.

TABLE 1 Medicinal materials: Efficacy and defects of Radix Aconiti,Momordica Cochinchinensis and Radix Aconiti Kusnezoffii MedicinalEfficacy and materials Medicine properties defects Radix AconitiMedicine properties: acrid and bitter in taste, hot in nature, RadixAconiti had extremely poisonous obvious effect on 1. AconitumCarmichaelii in “Wu Pu's Meteria Medica”, Shen antiinflammation Nong,Lei Gong, Tong Jun, Yellow Emperor: was sweet, and acesodyne, butpoisonous. has toxicity 2. Aconitum Carmichaelii in “Bie Lu”, was sweet,graet heat, extremely poisonous 3. In “Yao Xing Lun”, was bitter, acrid,great heat, extremely poisonous 4. In “Zhen Zhu Nang Bu Yi Yao Xing Fu”,was acrid and bitter, hot in nature, extremely poisonous, floating, yangwithin yang Toxicity: In “Chinese Materia Medica”, mice was given RadixAconiti apozem by gavage, LD50 was 18.0 ± 0.034 g/kg. People was givenAconitine by oral administration, fatal dosage was about 2~5 mg, LD50 bysubcutaneous injection was 0.32 mg/kg for mice, mice was givenmesaconitine by subcutaneous injection, fatal dosage was 0.3~0.5 mg/kg.Cautions: In “Chinese Materia Medica”, Radix Aconiti soaked and decoctedwith wine may cause toxicity, people should be cautious. If it was usedimproperly to lead to poisoning, the symptom includes tongue, limbs andsystematic numbness, salivation, nausea, vomit, diarrhea, dizziness,blur version, dry mouth, slow pulse, dyspnea, tetany, insanity, gatism,blood pressure and temperature dropped. One with severe poisoning mightdie resulted from the respiratory and circulatory failure and severecardiac arrhythmia. Momordica Medicine properties: bitter and slightlysweet in taste, warm in Momordica Cochinchinensis nature, poisonousCochinchinensis 1. In “Wang Mu”, bitter and slightly sweet in taste,mildly has effect on poisonous detumescence and 2. In “Yao Xing QieYong”, bitter in taste, great cold in nature lump dissipation, 3. In“Yao Xing Kao”, mildly poisonous, cool detoxication, Cautions: pregnantwoman and persons with body weakness chasing wind and must not take in.pain-alleviating, but 1. In “Collected Works of Materia Medica”, peoplewith had high irritation stomach deficiency, whose large intestine isnot material and true origin has no damage, can not use. 2. In “ShengCao Yao Xing Bei Yao”, fishy in taste, poisonous, can not be taken in.Radix Aconiti Medicine properties: acrid and bitter in taste, hot innature, Radix Aconiti Kusnezoffii extremely poisonous Kusnezoffii has 1.Aconitum Carmichaelii in “Wu Pu's Meteria Madica”, Shen obvious effecton Nong, Lei Gong, Tong Jun, Yellow Emperor: was sweet, antiinflammationpoisonous. and acesodyne, but 2. Aconitum Carmichaelii in “Bie Lu”, wassweet, great heat, has toxicity extremely poisonous 3. In “Yao XingLun”, was bitter, acrid, great heat, extremely poisonous 4. In “Xin XiuBen Cao”, acrid sweet, warm in taste, great hot, extremely poisonousToxicity: In “Chinese Materia Medica”, mice was given with AconitumCarmichaelii (Radix Aconiti Kusnezoffii) extract by oral administration,LD50 (dried herb) was 1827 ± 11.4 mg/kg, 5780 ± 4.4 mg/kg for AconitumKusnezoffii. LD50 of Aconitum Carmichaelii by intraperitoneal injectionwas 1.62 ± 1.1 mg/kg, 435 ± 4.4 mg/kg for Aconitum Kusnezoffii.Cautions: In “Chinese Materia Medica”, Radix Aconiti soaked and decoctedwith wine may cause toxicity, people should be cautious. Excessivedosage might cause toxicity, poisoning symptom might refer to “RadixAconiti”.

Additionally, Panchrest plaster from ancient formula mainly appliesoleum sesami to extract the effective ingredients, which can destroy theingredients in medicinal materials because of high temperature, or leadto the incomplete extraction of the effective ingredients, it is noteasy to manage and when molding, due to add lots of zinc oxide, theproblem of heavy metal residue is caused.

Therefore, it is necessary to provide a Chinese herbal medicinecomposition used for antiinflammation, detumescence and acesodyne, so asto solve the above problems.

SUMMARY OF THE INVENTION

The present invention provides a Chinese herbal medicine compositionused for antiinflammation, detumescence and acesodyne, comprising afirst type of medicinal materials and a second type of medicinalmaterials, wherein the first type of medicinal materials include RhizomaBletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, Radix AngelicaeSinensis, Paeonia Lactiflora, Rhizoma Notopterygii, Radix Linderae,Glycyrrhizae, Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei,the second type of medicinal materials is one, two or three selectedfrom the group cosisting of Zingiber Officinale, Olibanum and Myrrha.

The present invention further provides a Chinese herbal medicineextractive, prepared by a process comprising the following steps:providing a first type of medicinal materials and a second type ofmedicinal materials, wherein the first type of medicinal materialsinclude Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae,Radix Angelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii,Radix Linderae, Glycyrrhizae, Radix Angelicae Pubescentis, and Radix EtRhizoma Rhei, which are basic medicinal materials, and the second typeof medicinal materials is one, two or three selected from the groupconsisting of Zingiber Officinale, Olibanum and Myrrha, which are addedmedicinal materials; adding the first type of medicinal materials andteh second type of medicinal materials into a container with organicsolvent, making the percent by weight of the first and second type ofmedicinal materials with the organic solvent reach 1:N, so as to form afirst mixed solution, wherein N is a number between 3 and 12; heatingthe first mixed solution to a first predetermined temperature andperforming the extraction for a first predtermined time, so as to carryout first extraction, filtering the first mixed solution while hot, toachieve filtrate from the first extraction.

The present invention further provides a preparation method of a Chineseherbal medicine extractive, wherein the preparation method comprises thefollowing steps: providing a first type of medicinal materials and asecond type of medicinal materials, wherein the first type of medicinalmaterials include Rhizoma Bletillae, Cortex Cinnamomi, Radix AngelicaeFormosanae, Radix Angelicae Sinensis, Paeonia Lactiflora, RhizomaNotopterygii, Radix Linderae, Glycyrrhizae, Radix Angelicae Pubescentis,and Radix Et Rhizoma Rhei, which are basic medicinal materials, and thesecond type of medicinal materials is one, two or three selected fromthe group consisting of Zingiber Officinale, Olibanum and Myrrha, whichare added medicinal materials; adding the first and second type ofmedicinal materials into a container with organic solvent, making thepercent by weight of the first and second type of medicinal materialswith the organic solvent reach 1:N, so as to form a first mixedsolution, wherein N is a number between 3 and 12; heating the firstmixed solution to a first predetermined temperature and performing theextraction for a first predtermined time, so as to carry out a firstextraction, filtering the first mixed solution while hot achieving afiltrate from the first extraction.

The present invention further provides an use of the Chinese herbalmedicine composition, for example, the Chinese herbal medicinecomposition is used for Chinese herbal medicine patch, Chinese herbalmedicine paste and oral preparation.

The present invention provides a Chinese herbal medicine compositionused for antiinflammation, detumescence and acesodyne, which does notcomprise Radix Aconiti, Momordica Cochinchinensis, Radix AconitiKusnezoffii, Radix Rehmanniae, Ampelopsis Japonica, Radix SophoraeFlavescentis, Radix Scrophulariae. Thus, the Chinese herbal medicinecomposition used for antiinflammation, detumescence and acesodyneaccording to the present invention, is completely different fromoriginal formula of panchrest plaster. Moreover, it has been verifiedthat Radix Aconiti, Momordica Cochinchinensis, Radix Aconiti Kusnezoffiihave toxicity and dermal irritation; therefore, the Chinese herbalmedicine composition according to the present invention does not havedefects which original formula of panchrest plaster has. Additionally,compared with original formula of panchrest plaster, the Chinese herbalmedicine composition according to the present invention furthercomprises the added medicinal materials (such as Zingiber Officinale,Olibanum and Myrrha) so as to enhance efficacy.

The present invention chooses effective Chinese herbal medicine whichhas no irritation and anaphylaxis on skin and body, and applies specialextraction and preparation method and animal test methods to verify theefficacy of antiinflammation, detumescence and acesodyne, which isdifferent from the traditional panchrest plaster and commercial Chineseherbal medicine patch. The invention is illustrated in detail combinedwith figures below.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a flow chart for illustrating the first embodiment of thepreparation method according to the present invention.

FIG. 2 is a flow chart for illustrating the second embodiment of thepreparation method according to the present invention.

FIG. 3 is a stereoscopic diagram for showing the Chinese herbal medicinepatch having the Chinese herbal medicine composition according to thepresent invention.

FIG. 4 is a section drawing for showing the Chinese herbal medicinespray having the Chinese herbal medicine composition according to thepresent invention.

FIG. 5 is a stereoscopic diagram for showing the Chinese herbal medicinepaste having the Chinese herbal medicine composition according to thepresent invention.

FIGS. 6A to 6L are fingerprints for each kind of medicinal materialanalyzed by HPLC.

FIG. 7 is a fingerprint for the Chinese herbal medicine compositionaccording to the present invention analyzed by HPLC.

FIG. 8 is a diagram of HPLC results for the percutaneous experiment ofextractum having the medicinal material ingredients according to thepresent invention.

FIG. 9 shows average value of writhing determined by mice acetic acidwrithing test.

FIG. 10 shows licking feet time determined by mice Formalin test.

FIG. 11 shows results of antiinflammation, detumescence and acesodynetest for the Chinese herbal medicine patch according to the presentinvention.

DETAILED DESCRIPTION OF THE EMBODIMENTS

The invention provides a Chinese herbal medicine composition; thecomposition comprises a first type of medicinal materials and a secondtype of medicinal materials. Wherein, the first type of medicinalmaterials include Rhizoma Bletillae, Cortex Cinnamomi, Radix AngelicaeFormosanae, Radix Angelicae Sinensis, Paeonia Lactiflora (such as RadixPaeoniae Rubra), Rhizoma Notopterygii, Radix Linderae, Glycyrrhizae,Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei, which are basicmedicinal materials. The second type of medicinal materials is one, twoor three selected from the group cosisting of Zingiber Officinale,Olibanum and Myrrha, which are added medicinal materials. Specifically,the Chinese herbal medicine composition according to the presentinvention includes seven kinds of combinations of medicinal materials asshown in Table 2.

TABLE 2 Medicinal materials of the invention Basic medicinal materialsRadix Radix Rhizoma Cortex Angelicae Angelicae Paeonia Rhizoma RadixBletillae Cinnamomi Formosanae Sinensis Lactiflora Notopterygii LinderaeThere are 11 Yes Yes Yes Yes Yes Yes Yes kinds in the first combinationThere are 11 Yes Yes Yes Yes Yes Yes Yes kinds in the second combinationThere are 11 Yes Yes Yes Yes Yes Yes Yes kinds in the third combinationThere are 12 Yes Yes Yes Yes Yes Yes Yes kinds in the forth combinationThere are 12 Yes Yes Yes Yes Yes Yes Yes kinds in the fifth combinationThere are 12 Yes Yes Yes Yes Yes Yes Yes kinds in the sixth combinationThere are 13 Yes Yes Yes Yes Yes Yes Yes kinds in the seventhcombination Medicinal materials of the invention Basic medicinalmaterials Radix Radix Et Added medicinal materials Angelicae RhizomaZingiber Glycyrrhizae Pubescentis Rhei Officinale Olibanum Myrrha Thereare 11 Yes Yes Yes Yes None None kinds in the first combination Thereare 11 Yes Yes Yes None Yes None kinds in the second combination Thereare 11 Yes Yes Yes None None Yes kinds in the third combination Thereare 12 Yes Yes Yes Yes Yes None kinds in the forth combination There are12 Yes Yes Yes Yes None Yes kinds in the fifth combination There are 12Yes Yes Yes None Yes Yes kinds in the sixth combination There are 13 YesYes Yes Yes Yes Yes kinds in the seventh combination

When the second type of medicinal materials is one selected from thegroup consisting of Zingiber Officinale, Olibanum and Myrrha, theChinese herbal medicine composition contains 11 kinds of medicinalmaterials, percent by weight of each medicinal material is in the rangeof 9.09%±5%. When the second type of medicinal materials is two selectedfrom the group consisting of Zingiber Officinale, Olibanum and Myrrha,the Chinese herbal medicine composition contains 12 kinds of medicinalmaterials, percent by weight of each medicinal material is in the rangeof 8.33%±5%. When the second type of medicinal materials is threeselected from the group consisting of Zingiber Officinale, Olibanum andMyrrha, the Chinese herbal medicine composition contains 13 kinds ofmedicinal materials, percent by weight of each medicinal material is inthe range of 7.69%±5%.

In the present invention, the first type of medicinal materials is basicmedicinal materials, and the second type of medicinal materials is addedmedicinal materials. 7 kinds of combinations of medicinal materials inTable 2 all have efficacy of the invention. In the context below, onlytake the seventh combination for example, which comprises 13 kinds ofmedicinal materials in the Chinese herbal medicine composition (that is,Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, RadixAngelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii, RadixLinderae, Glycyrrhizae, Radix Angelicae Pubescentis, Radix Et RhizomaRhei, Zingiber Officinale, Olibanum and Myrrha), the other 6combinations can be carried out in the similar means, so it is notnecessary to give more details here.

Table 3 shows the comparision between the formula of the Chinese herbalmedicine composition used for antiinflammation, detumescence andacesodyne according to one embodiment of the present invention andoriginal formula of panchrest plaster.

TABLE 3 Medicinal materials Radix Radix Radix Radix Momordica AconitiRadix Ampelopsis Sophorae Rhizoma Rhizoma Cortex Angelicae AconitiCochinchinensis Kusnezoffii Rehmanniae Japonica Flavescentis BletillaeBletillae Cinnamomi Sinensis Formula Yes Yes Yes Yes Yes Yes Yes Yes YesYes of panchrest plaster Formula None None None None None None None YesYes Yes of the present invention Medicinal materials Radix Radix RadixEt Angelicae Paeonia Rhizoma Radix Angelicae Rhizoma Zingiber SinensisLactiflora Notopterygii Linderae Glycyrrhizae Pubescentis RheiOfficinale Olibanum Myrrha Formula Yes Yes Yes Yes Yes Yes Yes None NoneNone of panchrest plaster Formula Yes Yes Yes Yes Yes Yes Yes Yes YesYes of the present invention

The Chinese herbal medicine composition used for antiinflammation,detumescence and acesodyne of the present invention does not compriseRadix Aconiti, Momordica Cochinchinensis, Radix Aconiti Kusnezoffii,Radix Rehmanniae, Ampelopsis Japonica, Radix Sophorae Flavescentis,Radix Scrophulariae. Thus, the Chinese herbal medicine composition usedfor antiinflammation, detumescence and acesodyne according to thepresent invention, is completely different from original formula ofpanchrest plaster. Moreover, it has been verified that Radix Aconiti,Momordica Cochinchinensis, Radix Aconiti Kusnezoffii have toxicity anddermal irritation; therefore, the Chinese herbal medicine compositionaccording to the present invention does not have defects which originalformula of panchrest plaster has. Additionally, compared with originalformula of panchrest plaster, the Chinese herbal medicine compositionaccording to the present invention further comprises the added medicinalmaterials (such as Zingiber Officinale, Olibanum and Myrrha) so as toenhance efficacy.

The Chinese herbal medicine composition used for antiinflammation,detumescence and acesodyne according to the present invention, theefficacy of medicinal materials recorded in the literature is shown inTable 4.

TABLE 4 Medicinal Taste, nature and materials Characters and ingredientsPharmacological action efficacy Glycyrrhizae CharactersImmunoregulation, Sweet in taste, ( Leguminosae The root is round in theform anticancer and anti-aging neutral in nature. sp.) of long strip, nobranches, Glycyrrhizin: enhancing the Having the effect of Alias: sweet60.5-98.6 mm in length. As weight of immune organs and invigoratinggrass, sweet for one with bark, tightness of raise the number ofleucocyte. spleen-stomach and grass root, surface differs, wrinkle isGlycyrrhiza polysaccharide: replenishing qi, Glycyrrhiza obvious, thefibrous roots and inducing r-interferon which heat-clearing anduralensis Fisch scale leaves thereof is red has immunoregulation effectetoxifying, expelling Use part: brown, brown or grey brown;Glycyrrhizin: having phlegm to stop rhizome, root the texture thereof issolid, and immunoregulation effect and cough, relieving the cuttingsurface on both inhibiting or relieving the spasm and pain, It ends issmooth, the section is growth of tumour. is used for fatigue fibroid,yellow white, Glycyrrhiza flavonoids: caused by qi mealiness, hasobvious ring antioxidation, eliminating deficiency, pattern andchrysanthemum superoxide anion and hydroxy palpitation, and core, hascharacteristic flavor, radical burnout, palpitation sweet in taste. Asfor one Treating ulcer and and severe without bark, it is light yellow,protecting liver, palpitation, qi appearance thereof is fibroid,anticoagulation and reducing deficiency and cross section of rhizome hasblood lipids blood less, knotted obvious cambium in Inhibiting gastricsecretion, clavus, ulcer and two-thirds of radius, medulla having theeffect of ulcer swelling, sore is small in the center, xylem resistance,enhancing throat, cough and and phloem are radial, and pancreatic juicesecretion. much sputum, section is fibroid. Protecting liver, reducinglung-heat and cough Ingredients blood lipids, antiarrhythmic andpanting, Triterpenoids: and inhibiting platelet lung-cold and cough 1.Glycyrrhetinic acid aggregation and panting, acute (Glycyrrhizin)Antibacterial action and pain in the abdomen Sweet ingredients inantitoxin etc. It is also used Glycyrrhizae High dosage of Glycyrrhizinfor relieving 2. Glycyrrhiza saponins can inhibit copy of SARS virusmedicine nature, A₃, A₂, C₂ . . . and has the effect of gastric and 3.Flavonoid detoxication duodenum ulcer, Glycyrrhiza flavonoidsAntiinflammation and heat stranguria and Glycyrrhiza Liquiritindetumescence dysuria, AIDS. and so on Glycyrrhetinic acid and 4.Polysaccharide derivative thereof can inhibit 5. Alkaloid bloodpermeability of histamine, can be made into antiinflammation andantiallergic preparation used for rheumatic arthritis, allergicdermatitis and asthma Cosmetics Reducing or removing toxic substances incosmetics, preventing allergic reaction on somebody, additionally,strongly inhibiting tyrosinase action Zingiber Characters Sedation,acesodyne and Bitter in taste, warm Officinale Flat and in the form ofantiinflammation in nature, non-toxic. (Zingiberaceae) irregular mass,having digitate Extracting solution from Function is warming Use part:dried branches. Length: 1-6 cm, zingiber Officinale by the middle-Jiaorhizome thickness: 0.4-2 cm. Surface methanol, can lengthen the mildlyand is gray or yellowish gray, sleeping time of anaesthetic removingcold, rough, having longitudinal mice, obviously inhibit eliminatingwrinkles and obvious rings, writhing reaction reduced by dampness andhave scale leaves remaining in acetic acid in mice, can also removingphlegm, ramose place. Appearance of inhibit blood permeability stoppingvomit and medicinal materials without caused by acetic acid, and treatdiarrhea, bark is yellow white or light rheumatic arthritisstrengthening brown, smooth and have Effect on heart and blood stomachicand lognitudinal pinstripe. It is Zingiber Officinale extractiveanalgesia, warming solid in texture, section is can lead to transientrise of channels and graininess, gray or light blood pressure in rats bystopping bleeding. yellow, one with soft texture intravenous injection.It is mainly used for has visual venation, thin Effect on digestivesystem loin pain and blood grease oil balls and obvious Water extractivefrom fresh stasis. rings, aromatic in smell zingiber Officinale caninhibit atmosphere, spicy in taste. tonicity gastric ulcer andIngredients stimulate obviously and cause β-Pinene intestinal canal tocontract Myrcene Antihypoxic effect γ-Selinene, Nonanol Ether exactivefrom zingiber β-Sesquiphe-l landrene Officinale can reduce amountGingerol of oxygen consumption in Zingiberone mice, and extend survivaltime Zingerone after potassium hydroxide Zonaren poisoning. ShogaolOlibanum Characters: Effect on treating stomach Spicy and bitter in(Burseraceae) Lentisks are small shrubs, the and duodenum ulcer taste,warm in Alias: trunk is thick and slippery, can Feeding rats for a longtime, nature. Function Rushixiang, be peeled off like paper. It is canredue obviously ulcer includes activating Taxiang, in the form ofspherelike, index and free acidity of blood analgesia, Tianjinxiangguttate particle or irregular gastric contents detumescence and Usepart: resin small mass, some is sticky and Antiinflammation promotingspilled from form mass, is light yellow, Olibanoresin is an granulation.It is bark of lentisk light blue-green or palm red, anti-inflammatoryingredient, used for pain in the translucent. It is solid in can reduceglycosaminoglycan abdomen, texture, aromatic in smell, very in skin,liver, kidney and Rheumatic bitter in taste, it becomes soft spleen ofrats after eating, arthralgia, physical to be gum when chewing. which isrelated with injuries, line of Ingredients: anti-inflammatory effect.abdominal pain, resin 60~70% Reduce cholesterin ulcer and swellingα-boswellic acid, β-boswellic Feeding rats can reduce the orslow-healing after acid, lactic acid resin synthesis of cholesterin inulceration etc. hydrocarbon . . . liver. gum 27~35% Acesodyne Arabtanning polysaccharide Olibanum has obvious acid acesodyne effectverified by volatile oil 3~8% writhing experiment induced amyrenone,pinocamphone, by acetic acis phellandral . . . Paeonia Character:Antitumor function: Bitter in taste, Lactiflora Root is cylindrical,slightly Water or ethanol extractive of slightly cold in (Ranunculaceae)curved, 4-8.5 cm in length, Radix Paeoniae Rubra can nature, go intoliver Alias: wood about 9.1-11.1 mm in increase the content of cyclicand spleen channel. Paeonia diameter, surface is dark adenosinemonophosphate Function includes lactiflora brown with thick and deep(cAMP) in tumor cells, so as to clearing away heat Use part: rootlongitudinal wrinkles, bark is enhance anticancer action. and coolingblood, easy to fall off to show white Antibacterial action: activatingblood and or light brown cortex, texture It can inhibit shigelladissolving stasis, thereof is hard and brittle, dysenteriae, pseudomonasdetumescence broken off easily. The aeruginosa, staphylococcusanalgesic. It is section is fibroid, yellow aureus, and damage theeffect used for pyreticosis white, mealiness, has obvious of aflatoxinB1. Benzoic acid and eruption, rings and chrysanthemum can be used aspreservative traumatic injury, hot core, has characteristic flavor, withother Chinese herbal eyes etc.. In recent sweet in taste. medicine, hasgood curative years, it can be used Ingredients: effect on infectiousacne. for treating arteria 0.72% of benzoic acid Antithrombotic actioncoronaria rencently. volatile oil, fatty oil, resin Paeoniflorin,d-catechin and tannin analogous prostacyclin are sugar, starch powerfulblood vessel lymphatic temperament relaxation agent, and inhibit proteinplatelet aggregation to have paeoniflorin 1.8%~7.3% antithromboticfunction. Whitening effect: Since having obvious effect on activatingblood and dissolving stasis, it has effect on butterfly rash, freckleand pigment precipitate; it can be used for a long time because it isnon-hormonal whitening expelling spot agent without any side effects.Paeoniflorin also has sedation, analgesic, relieving spasm andanti-inflammatory effect. Radix Paeoniae Rubra contains tannins whichcan affect the activity of SOD, therefore it has a powerful antioxidantability. Radix Linderae Characters: Gastrointestinal regulatory Spicy intaste, warm (Lauraceae) It is cylindrical or spindle, role in nature.The Alias: nodular enlargement, 5-15 cm It has bidirectional effect onfunction includes TongQianCai, in length, 0.5-2.5 cm in gastrointestinalsmooth promoting qi TianTaiWuYao, diameter, appearance is yellow muscle,can promote or inhibit circulation and Short ZhangGen brown to darkbrown, have gastrointestinal activities. relieving pain, Use part: dryfine wrinkle ring crack and Antibacterial aciton and warming kidney androot lateral root mark, the bark is treating herpes simplex viruseliminating cold. easy to peel off and show Cultivating with virus canIt is used for chest fibrous wood, texture thereof restrain virus withhigh distress and is solid and is hard to break efficiency. costalgia,pain in off. Section of part without Stop bleeding and promoting gastralcavity, bark is spherelike or irregular blood coagulation regurgitationand shape, cutting surface is light Vitro experiments prove Radix vomit,pain in belly brown and reddish, radicals Linderae powder can caused bycold, line and annual rings are visible, obviously reduce plasma ofabdominal pain, aromatic in smell, slight calcification time, andpromote frequent urination flavour in taste, and has blood coagulation.and enuresis etc . . . irritative cool. Antihistamine action IngredientsAlcohol extractive of Radix linderalactone, Linderae root hasisolinderalactone, antihistamine role on trachea isolinderoxide,linderene, of guinea pigs. neolinderalactone, isohexylfuran,laurolitsine, sesquiterpenoids. Radix Characters: Antimicrobial effectSpicy in taste, warm Angelicae Root is cone, surface is gray It has acertain inhibition effect in nature. Function Formosanae yellow toyellow brown. on escherichia coli, shigella includes expelling(Umbelliferae) Hole in the bark is visible and dysenteriae, typhoidbacillus wind and relieving Alias: Fragrant scatters protuberantly incoli, paratyphoid bacillus, exterior, relieving angelica transverse,which is called pseudomonas aeruginosa and pain, treating nasaldahurica, “geda ding”. Section is proteus, choleraic vibrio etc..obstruction, Aromatic chuan mealiness, and brown grease Antipyretic,analgesia and detumescence and angelica spots scatter in cortex, formanti-inflammatory action apocenosis, dahurica ring, xylem accounts forabout Water extractive has a certain eliminating Use part: root a thirdof the section, strongly effect on detumescence for dampness andfragrant in smell, taste sweet relieving pain and skin arrestin. It isused and slightly bitter. pruritus. for headache by Ingredients:Cosmetics cold, superciliary Containing volatile oil, many It has theeffect of whitening ridge pain, gum kinds of coumarin derivatives skin,sunscreen, prevent UV, pain, feeling but because containing furanfullness in the head, coumarin compounds, it has nasal obstruction,photosensitivity turbid nasal mucus, Effect on fat metabolism acute andchronic It can enhance the fat sinusitis, cold wet decompositionfunction leucorrhea, clear induced by adrenaline and leucorrhea,swelling ACTH, and inhibit glucose and boils, acute induced by insulinfrom mastitis pain, changing into fat. expelling wind and relievingitching, pruritus by wind etc . . . Radix Characters Treat arthritis,analgesic and Spicy and bitter in Angelicae Taproot is slightlycylindrical, sedation taste, slightly warm Pubescentis has branches,10-30 cm in Rhizoma Notopterygii and in nature. Function (Umbelliferae)length. Reed head is Radix Angelicae Pubescentis inludes expellingAlias: Fragrant enlargement, has many can expel rheumatism, butrheumatism, angelicae horizontal wrinkles, and has a efficacy of Rhizomarelieving pain, Pubescentis, diameter of 1.5-3 cm. There Notopterygii islarger and removing Large angelicae is stem and leaf residual basesacute, it gets into taiyang obstruction, Pubescentis, or depression onthe top, (bladder) channel, is good at eliminating cold and Chuanangelicae surface is greyish brown or treating headache caused byrelieving exterior. Pubescentis, Yu brown, has longitudinal rheumatism(one with more It is used for Huo wrinkles, and has protuberance severeoccipital pain, the wind-cold-dampness Use part: lenticel on bark intransverse efficacy is better), limbs pain arthralgia, rhizome andprotuberant fine root and body pain. arthralgia, achiness marks. It ishard in texture, Powder of Radix Angelicae in loin and knees, sectionhas brown rings, bark Pubescentis is milder than paralysis in two feet,is grey-white, brown grease Rhizoma Notopterygii, it gets stretchdisadvantage spots scattered is visible; into shaoyin channel (kidneyand wind-cold xylem is sallow to channel), is good at treating exteriorsyndrome yellowish-brown. wind of shaoyin channel, with damp evil etc.,Ingredients: mainly used for pain of waist, is also applied forCoumarins such as knees and foot shin. diaphoresis, Angelicon Directlydilating blood sedation, diuresis Angelol vessels and lower blood andshrinking blood Bergapten pressure vessels. Angelical Dogs and cats aregiven crude Psoralen preparation of Radix Byakangelicin AngelicaePubescentis by intravenous injection, which has antihypertensive effect,but is not lasting, additionally, it has the effect of shrinking bloodvessels. Effect on platelet aggregation It has influence on plateletaggregation of rats, and may reduce the formation of vein thrombosis.Photosensitive role Radix Angelicae Pubescentis contains furan coumarincompounds such as Bergapten, xanthotoxin, which are photosensitive, canlead to photo sensitivity when shined by sun or UV. Antibacterial actionFuran coumarin compounds in the status of light sensitivity generallyhave no obvious antibacterial activity, but can kill bacteria uponexposure. But rats are given xanthotoxin and bergapten by intravenousinjection, LD50 are respectively 160 mg/kg, 945 mg/kg. Radix Characters:Have anti-thrombotic and Sweet and spicy in Angelicae Root head andTaproot are antanemic effect, improve taste, warm in Sinensis rough,there are bud mark, liver and lung nature. Function (Umbelliferae) stembase and petiole base Relieving thrombus formation, includes Alias: YunGui, remained on the top. There promoting the generation ofhematogenesis and Gan Gui, Qing are more than 10 tails under hemoglobinand the red blood activating blood Gui, Xi Dang root head and taproot,tail is cells. circulation, relieving Gui thick above and thin below,For chronic liver disease, constipation with Use part: root many ofwhich is distortion. relieving the liver fibrosis and laxatives. It isSurface has fibrous root mark promoting liver cell function used forblood like knots. It is dry, hard in recover. deficiency and texture,become soft and Improving lung ventilation chlorosis, pliable in texturewhen function, strengthening palpitations and absorbing moisture.Section physical strength. dizziness, abnormal is yellow white withcranny; Have immune and menstruation, there are light brown rings andanticancer effect, amenorrhea and many brown oil spots in theantiinflammation and dysmenorrhea, middle layer. Greatly Antibacterialaction deficiency-cold fragrant in smell, sweet and Ferulic acid sodiumand abdominal pain, slightly spicy in taste. angelica polysaccharide canintestinal dry Ingredients ascend phagocytosis of constipation, Volatileoil: macrophages, promote rheumatic arthralgia, Acidity: (2%; palmiticacid, lymphocyte transformation, traumatic injury, phthalic anhydride)can be used for the treatment carbuncle and ulcer. Phenolic: (10%;carvacrol) of cancer, especially for Used with alcohol Neutral: (88%,two kinds of gynecological tumors. can activate blood sesquiterpene,n-butylidene The effect of angelica circulation and have phthalide,angelica ketone) extractive on vascular emmenagogic Water-solubility:permeability and inhibiting effect. It is used ferulic acid, angelicaplatelet causing inflammation for treating polysaccharide, is similarwith aspirin. amenorrhea and stigmasterol-D-glucoside etc. Inhibitinggolden dysmenorrhea. Cholate, 17 kinds of amino staphylococcus,pseudomonas acid aeruginosa and colibacillus. 23 kinds of inorganicelements Anti-aging action Ferulic acid can inhibit lipid peroxidation,and directly eliminate radicals. Myrrha Characters: AntiatheroscloresisBitter and spicy in (Burseraceae) It is irregular particles, or The partcontaining resin oil taste, neutral in Alias: Mo Yao, sticks into mass,with a can reduce high cholesterol of nature, nontoxic. Ming Mei Yaodiameter of about 2.5 cm, has male rabbit fed with Function includes Usepart: resin smaller or larger ones. Surface hydrogenated oil, canprevent activating blood spilled from is red brown or yellow brown, theformation of artery wall circulation and myrrha bark rough, is coveredwith powder. plague, also reduce rabbit removing It is hard and brittlein texture, weight. blood-stasis, easy to craze, the section is inConvergent effect removing bruises the form of particle, has brown Myrrhtincture has the and relieving pains, luster, is translucent, often hasconvergent effect on mucous treating traumatic white spots or texture,has membrane, it can be used as injury, pain in bones characteristicflavor, very oral lotion when occurring oral and heart, bitter in taste.cavity and pharynx ulcer, and abdominal mass, Main ingredients: it isalso used for stimulating gynecological mass, Resin is 25-35%, volatileoil is intestines and stomach amenorrhea, ulcer 2.5-9%, gum is about57-65%, peristalsis. and swelling, anal water and various kinds ofAnti-inflammatory, analgesic fistula, invisibility. tannins is about3-4%. and defervescence The action of Myrrh terpenol includes 500 mg/kgof Myrrh extractive activating blood eugenol, meta-cresol, is applied torat by stomach circulation and cuminaldehyde, pinene, irrigation; it hassignificant removing cinene, limonene, inhibition effect onblood-stasis, cinnamaldehyde, heerabolene, inflammation, which is calledremoving bruises etc. Gum is hydrolyzed into defervescence reaction. andrelieving pains arab sugar, galactose and Antibacterial action issimilar with xylose. Water extractive of Myrrh has Olibanum. It isdifferent degree of effect on mainly applied for various pathogenicfungi such traumatic pain and as tinea bacteria in tube. amenorrheaetc., also used for chest pain in heart and chest caused by qi stagnancyand blood stasis. Rhizoma Charaters: Antipyretic, analgesic and Bitterand spicy in Notopterygii Rhizome is cylindrical, has anti-inflammatoryeffect taste, warm in (Umbelliferae) different length, with a Rats testshows that it has nature. Function Alias: Chuan diameter of 1-3 cm.antipyretic ability, clippling includes expelling Qiang, Kuan YeAppearance is brown-black, tail and burning tail test shows wind andrelieving Qiang Huo, node is dense in the upper that RhizomaNotopterygii has exterior, relieving Chan Qiang, section, and rare inthe lower obvious analgesic effect, pain and Hei Yao section, has ridgyrings, has additionally, anti-swelling spasmolysis. It is Use part: drymany bud mark like strumae, experiment shows that used for cold, feverroot, rhizome has stem mark on the top. Rhizoma Notopterygii has bycold, rheumatic Root is cylinder or cone with antiphlogistic effect.arthralgia, headache, microgroove and branch root Effect againstmyocardial body pain, tetanus mark. It is loose in texture, ischemiaetc. It has section is not smooth, yellow Volatile oil of Rhizomaantibacterial action, white, delicate fragrance, Notopterygii can dilatediaphoresis, slightly spicy and bitter later in coronary artery,increase antipyretic action taste. Cross section or coronary arteryflow, and and analgesia. oblique section slice is round improve thestate of the or oblate, there is myocardial ischemia. chrysanthemumtexture on the Antibacterial action surface, the bark is brownish Inculture dish test, Rhizoma red, xylem is white, medulla is Notopterygiioil has obviously brown to black in the center, inhibiting effect ondysentery loose into hollow. bacillus, escherichia coli, Ingredients:pseudomonas aeruginosa, and Main ingredients: including goldenstaphylococcus aureus. volatile oil which is identified to be 20 types,accounting for 97.13%. Non-volatile oil contains columbianadin,notopterol, ferulic acid and coumarin. Cortex Characters Dilated effecton peripheral Bitter and sweet in Cinnamomi It is in the form of shallowvessel taste, hot in nature. (Lauraceae) groove or cannular, with aIncreasing myocardial Function includes Alias: Da Gui, length of 30-50cm, a width or contractility and times of heart warm middle and Mu Gui,Yu diameter of 3-10 cm, and a beat, and dilating arteria relieve cold,warm Gui, La Gui, Jun thickness of 2-8 mm. Surface coronaria, increasingblood kidney and promote Gui and Tong is grey brown, a light coarse,flow yang, get through Gui with horizontally protruding Anticoagulationthe meridians, warm Use part: bark skin holes and fine wrinkles. CortexCinnamomi extractive qi and blood. It is Inner is brownish red and withmethanol can inhibit used for pain by smooth, has fine lines. It isplatelet aggregation, cinnamic spleen and stomach hard and brittle intexture, acid has antithrombin action. deficiency and cold, section isgraininess, outer strengthening the stomach chill and limbs cold, layeris brown, inner layer is action and removing impotence and red brown andoily, there is a spasmodic pain of stomach frequent micturition, lightyellow line (stone cells Cortex Cinnamomi oil is yang deficiency ofband) between two layers. aromatic stomachic spleen and kidney, The barkwhich is closer to the carminative, can relieve the pain in belly andcenter of the trunk, has higher irritation on stomach and loose stool,quality. Strong fragrant in intestine, can enhance amenorrhea by cold,smell, taste sweet and spicy. secretion of saliva and gastric pain inbelly by Ingredients: juice, and remove smooth amenorrhea, pain byVolatile oil: cinnamaldehyde, muscle spasm of stomach and cold anddampness, cinnamyl acetate intestine. aeipathia weakness,Antiinflammation weak qi and blood Cortex Cinnamomi has a deficiency,swelling certain inhibiting effect on from yin carbuncle, acute andchronic there is no ulcer inflammation, can inhibit feet even ifpurulence swelling of rats and increase of forms, ulcer which capillarypermeability. is not healed for a Antibacterial action long time,bladder Cinnamaldehyde has strong deficiency and cold, bactericidalaction, especially urinary obstruction for dermatophytes. etc . . .Rhizoma Characters Hemostasis Bitter and sweet in Bletillae It is flatlike palm, young Film prepared with extractive taste, cold in nature.(Orchidaceae) rhizome is fleshy, and solution of Rhizoma BletillaeFunction includes Alias: Bai Ji, branches are short. Surface is roottuber can be used for relieving cough, Lian Ji Cao, Bai smooth andalmost white, with experimental wound bleeding removing heat and Ji, GanGen, Zi a diameter of 2-3 cm and a of dogs and rabbits detoxicating, LanGen thickness of about 3 mm, has Protection for mucous promoting tissueUse part: stem scars, root tuber mark membrane regeneration, rhizomebelow, fine roots mark with Reducing the damage of astringing wound.brown tache, scale leaves like mucous membrane reduced by It is used formembrane. It is hard in hydrochloric acid, but has no phthisis, cough,texture, and is not easy to effect on gastric secretion. hemoptysis andbreak off. Decoction pieces Anti-tumor effects traumatic injury. andtransverse section slice are Rhizoma Bletillae and Glucose translucentand keroid, have Injection have obviously scattered vascular bundleinhibiting effect on liver points. It has no flavor, light cancer ofrats. taste, is viscous. Ingredients: Tuber contains bibenzyl compounds,biphenanthrene compounds, biphenanthrene ethers compounds,dihydro-phenanthrene pyranoid compounds, phenanthrene derivative ofspironolactone, glucoside compound of phenanthrene, benzyl compounds,anthracene compounds, acid substances and aldehyde. Radix Et CharactersEffect on digestive system Bitter in taste, cold Rhizoma Rhei One, northRadix Et Rhizoma 1. Protecting liver and in nature. Function(Polygonaceae) Rhei is conical or toroidal gallbladder. 2 Treatingincludes eliminating Alias: Huang shape, with a length of 5-17 cmgastric and duodenum ulcer. dampness and heat, Liang, Jiang and adiameter of 3-10 cm, 3 Cathasis. 4 Has effect on discharging fire, Jun,Huo Shen, bark therof has been removed smooth muscle of bowel coolingblood, Fu Ru or retains a little. Outer bark Effect on pathogene,eliminating stasis Use part: is yellowish-brown or reddish microorganismand virus and detoxicating. rhizome brown, has almost white Have effecton bacteria, fungus It is mainly used for rhombus mesh texture, whichand virus material is commonly called as “Jin Effect on antitumorconstipation, mass Wen”, or has spiral “star” like Mice are given rheinand in the abdomen by chrysanthemum, one end often emodin byintraperitoneal hot, diarrhea has rope hole. It is hard in injection,have good inhibiting dysentery resulted texture, cross section is effecton melanin tumour and from dampness and yellowish-brown, and has ehrlichascites tumor of mice heat, jaundice, clap, particles, slightly oily. InAntiinflammation edema and full nearly peripheral place, it Radix EtRhizoma Rhei has abdomen, difficult accidentally has dark cambiumobvious inhibiting effect on urination, hot eyes, and radial orangebending various animal trial sore throat, tongue lines, special smell,taste bitter inflammation, can be used for festered, stomach and puckeryslightly. Two, traumatic injury, pain from heat with vomiting, SouthRadix Et Rhizoma Rhei stasis. The powder can be traumatic injury, isloose in texture, very placed on the wound besides pyretic toxicity,fibrous, has weak smell, the internal use, which can carbuncle andulcer. other is similar with north improve blood circulation and RadixEt Rhizoma Rhei. relieve bruises and relieving Ingredients; pain Mainingredients are Hemostasis anthraquinones derivative and Radix EtRhizoma Rhei is used tannin. for hemostasis for a long time, The contentof anthraquinones especially, efficacy in treating derivative accountsfor about digestive tract bleeding has 1-5%, free anthraquinones beenconfirmed in recent years derivative contains rhein, archen,chrysophanol, aloe-emodin and physcion. Combined anthraquinonesderivative contains double anthraquinone glycosides and singleanthraquinone glycoside. The content of tannin accounts for about 5%,contains galloyl glycosides, catechin, gallic acid and tetrarin.

The Chinese herbal medicine extractive of the present invention can beprepared by the process according to the first emdobiment of the presentinvention. As shown in FIG. 1, process according to the first embodimentof the present application comprises the following steps: in Step 100,providing the first type of medicinal materials and the second type ofmedicinal materials, wherein, the first type of medicinal materialsinclude Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae,Radix Angelicae Sinensis, Paeonia Lactiflora (such as Radix PaeoniaeRubra, Radix Paeoniae Alba), Rhizoma Notopterygii, Radix Linderae,Glycyrrhizae, Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei,which are basic medicinal materials. The second type of medicinalmaterials is one, two or three selected from the group cosisting ofZingiber Officinale (such as Rhizoma Zingiberis, Zingiber OfficinaleRoscoe), Olibanum and Myrrha, which are added medicinal materials. InStep 102, adding organic solvent (such as one or more selected frommethanol, ethanol, acetone, methyl ethyl ketone, kerosene (petroleumether) and hexane), putting the first and second type of medicinalmaterials and the organic solvent in the first container (that isextraction bucket), make the percent by weight between the first andsecond type of medicinal materials and the organic solvent reach 1:N, soas to form the mixed solution, N is a number between 3 and 12.Preferably, N is 8. In Step 104, heating the mixed solution to apredetermined temperature and performing the extraction for apredetermined time, so as to carry out the extraction, wherein thepredetermined temperature is between 30° C. and 100° C. If the organicsolvent is ethanol, the predetermined temperature is prefereably withinthe range of boiling point of ethanol ±5° C. The predetermined time isbetween 1 h and 6 h. In Step 106, filtering the mixed solution whilehot, achieving the filtrate and transferring it to the second container(that is measuring glass). In Step 108, condensing the filtrate into anextractum with a water content in the range of 10-40% by weight and acontent of the organic solvent in the range of 3-30% by weight.Preferably, condensing the filtrate into an extractum with a watercontent in the range of 10-20% by weight and a content of organicsolvent in the range of 5-10% by weight. The extractum is anintermediate product, which is convenient to be transported and saled,so as to prepare the final product. In Step 110, removing the residuefrom the container.

The Chinese herbal medicine extractive of the present invention can beprepared by the process according to the second embodiment of thepresent application. As shown in FIG. 2, the process according to thesecond embodiment comprises the following steps: in Step 200, providingthe first type of medicinal materials and the second type of medicinalmaterials, wherein, the first type of medicinal materials includeRhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, RadixAngelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii, RadixLinderae, Glycyrrhizae, Radix Angelicae Pubescentis, and Radix EtRhizoma Rhei, which are basic medicinal materials. The second type ofmedicinal materials is one, two or three selected from the groupcosisting of Zingiber Officinale, Olibanum and Myrrha, which are addedmedicinal materials. In Step 202, adding organic solvent, putting thefirst and second type of medicinal materials in the first container withorganic solvent (that is extraction bucket), make the percent by weightof the first and second type of medicinal materials with the organicsolvent reach 1:N, so as to form the mixed solution, N is a numberbetween 3 and 12. Preferably, N is 8. In Step 204, heating the mixedsolution to a first predetermined temperature and performing theextraction for a first predetermined time, so as to carry out a firstextraction, wherein the first predetermined temperature is between 30°C. and 100° C. If the organic solvent is ethanol, the firstpredetermined temperature is prefereably within the range of boilingpoint of ethanol ±5° C. The first predetermined time is between 1 h and6 h. In Step 206, filtering the first mixed solution while hot,achieving the filtrate and transferring it to the second container (thatis measuring glass). In Step 208, reserving the residue from the firstextraction. In Step 210, adding the organic solvent again, making thepercent by weight of the above medicinal materials with the organicsolvent reach 1:N again, so as to form a second mixed solution, N is anumber between 3 and 12. Preferably, N is 8. In Step 212, heating thesecond mixed solution to a second predetermined temperature andperforming the extraction for a second predetermined time, so as tocarry out the second extraction, wherein the second predeterminedtemperature is between 30° C. and 100° C. If the organic solvent isethanol, the second predetermined temperature is within the range ofboiling point of ethanol ±5° C. The second predetermined time is between1 h and 6 h. In Step 214, filtering the second mixed solution while hot,achieving the filtrate of the second extraction. In Step 216, mixing thefiltrate of the first extraction and the filtrate of the secondextraction. In Step 218, condensing the mixed filtrate into an extractumwith a water content in the range of 10-40% by weight and a content oforganic solvent in the range of 3-30% by weight. Preferably, condensingthe mixed filtrate into an extractum with a water content in the rangeof 10-20% by weight and a content of organic solvent in the range of5-10% by weight. The extractum is an intermediate product, which isconvenient to be transported and saled, so as to prepare the finalproduct. In Step 220, remove the residue of the second extraction fromthe container.

As shown in FIG. 3, the Chinese herbal medicine extractive of thepresent invention can be used in Chinese herbal medicine patch 300.Wherein the Chinese herbal medicine patch 300 comprises adhesive tapelayer 310 and Chinese herbal medicine layer 320. The Chinese herbalmedicine layer 320 is formed on the adhesive tape layer 310. In theembodiment, the Chinese herbal medicine layer comprises diluent andextractum of the Chinese herbal medicine according to the presentinvention. The extractum of the Chinese herbal medicine (intermediateproduct) is mixed with the diluent, so as to form the Chinese herbalmedicine layer (final product). The diluent includes ethanol, water andwater-based glue. The Chinese herbal medicine patch 300 has a content ofthe Chinese herbal medicine extractive in the range of 50-3500 mg/14 g(each piece of the Chinese herbal medicine patch).

As shown in FIG. 4, the Chinese herbal medicine extractive of thepresent invention can be used in Chinese herbal medicine spray. In theembodiment, the Chinese herbal medicine spray 400 comprises diluent andthe extractum of the Chinese herbal medicine according to the invention.The extractum of the Chinese herbal medicine (intermediate product) ismixed with the diluent, so as to form the Chinese herbal medicine spray(final product). The diluent includes ethanol, polyalcohol and water.The Chinese herbal medicine spray has a content of the Chinese herbalmedicine extractive in the range of 10-500 mg/g. In another embodiment,the Chinese herbal medicine spray does not contain the extractumobtained by condensed (intermediate product), but contains the filtrateobtained by the extractive without condensing (that is also anintermediate product), such that reducing the condensing procedures,leading to the shorten preparation time and reduced preparation cost.

As shown in FIG. 5, in the embodiment of the invention, the Chineseherbal medicine extractive can be used in Chinese herbal medicine paste500, which can be divieded into ointment, hydrogel and cream. TheChinese herbal medicine paste 500 comprises diluent and the extractum ofthe Chinese herbal medicine extractive according to the presentapplication. The extractum of the Chinese herbal medicine extractive(intermediate product) is mixed with the diluent, so as to form theChinese herbal medicine paste (final product). As for the ointment, thediluent comprises vaseline, white wax and nonionic surfactant; as forthe hydrogel, the diluent comprises ethanol, water and nonionicsurfactant; as for the cream, the diluent comprises grease, wax andemulsifier. The Chinese herbal medicine paste 500 has an average contentof the Chinese herbal medicine extractive in the range of 10-500 mg/g.

Furthermore, the Chinese herbal medicine extractive of the presentinvention can be used for oral preparation, which can be divided intopowder, pills and lozenge. In the embodiment, the oral preparationcomprises diluent and the extractum of the Chinese herbal medicineextractive of the present application. The extractum of the Chineseherbal medicine extractive (intermediate product) is mixed with thediluent, so as to form the oral preparation (final product). As for thepowder and pills, the diluent comprises starch and saccharides (such assugar or honey); as for the lozenge, the diluent mainly comprisescrystalline cellulose. The oral preparation has a content of the Chineseherbal medicine extractive in the range of 3-250 mg/g.

Additionally, the above-mentioned Chinese herbal medicine extractivecomprises the following 9 types of main indicative ingredients:Paeoniflorin, Ferulic acid, Cinnamaldehyde, Glycyrrhizin, Rhein,Imperatorin, Osthol, Isoimperatorin and Gingerol. Based on 1 g of theChinese herbal medicine extractive, the content of the indicativeingredients is respectively that, Paeoniflorin is 4.466-1.488 mg,Ferulic acid is 0.382-0.127 mg, Cinnamaldehyde is 2.159-0.720 mg,Glycyrrhizin is 9.677-3.226 mg, Rhein is 1.013-0.338 mg, Imperatorin is0.727-0.242 mg, Osthol is 1.389-0.463 mg, Isoimperatorin is 0.709-0.236mg, Gingerol is 0.144-0.432 mg.

The invention is futher illustrated by the following test examples andtest data.

TEST EXAMPLE 1

The irritant of each extractum of the Chinese herbal medicine on animalskin is tested.

The each medicinal material in original formula of Panchrest plaster andthe formula of the Chinese herbal medicine composition in the presentinvention is respectively put in an extractor with 95 wt % ethanol at aratio of 1:8 by weight, and is extracted for 3 h at 80° C., theextractive is repeated twice, two parts of extracting solution arecollected, then filtrated separeately, the filtrate is condensed by areduced pressure concentrator. 25 μL of the extractum, positive controland negative control substance is respectively applied to the skin of ananimal eliminated the hair on the back. After irritation for 24 h, theskin reaction is observed and recorded after 24 h, 48 h and 72 h.According to the dermal irritation scoring system evaluation method (asshown in Table 5) and Primary Dermal Irritation Index (as shown in Table6), the degree of dermal irritation is evaluated (as shown in Table 7).

TABLE 5 Dermal irritation scoring system evaluation method Dermalresponse Score Erythema and Eschar Formation No erythema 0 Very slighterythema (barely perceptible) 1 Well-defined erythema 2 Moderate tosevere erythema 3 Severe erythema (beet redness) to slight escharformation (injuries 4 in depth) Necrosis (depth of tissue) +N Eschar(sloughing or scab formation) +E Edema Formation No edema 0 Very slightedema (barely perceptible) 1 Slight edema (edges of area well-defined bydefinite raising) 2 Moderate edema (raised approximately one millimeter)3 Severe edema (raised more than one millimeter and extending 4 beyondthe area of exposure)

TABLE 6 Primary Dermal Irritation Index PDII = 0 Nonirritant PDII =0.0-0.5 Negligible irritant PDII = 0.5-2.0 Mild irritant PDII = 2.0-5.0Moderate irritant PDII = 5.0-8.0 Severe irritant Primary DermalIrritation Index (PDII) = score/observed times Observed times = Observeddays × number of tested animals Results: the higher PDII score is, thestronger dermal irritant is

TABLE 7 Degree of dermal irritation Ingredient PDII 1 PC 1.33 2 RadixAngelicae 0.33 Formosanae 3 Rhizoma Notopterygii 1.00 4 Radix Sophorae0.00 Flavescentis 5 Rhizoma Bletillae 0.56 6 Momordica 4.00Cochinchinensis 7 Radix Scrophulariae 0.56 8 Radix Rehmanniae 0.56 9Ampelopsis 0.22 Japonica 10 Glycyrrhiza 0.22 11 Radix Linderae 0.33 12Radix Paeoniae 0.33 Rubra 13 Cortex Cinnamon 0.78 14 Radix Aconiti 0.89Kusnezoffii 15 Radix Aconiti 1.00 16 Radix Angelicae 0.78 Sinensis 17Radix Angelicae 0.44 Pubescentis 18 Radix Et 0.33 Rhizoma Rhei 19Rhizoma Zingiberis 1.80 20 Olibanum 0.00 21 Myrrha 0.00 22 Panchrestplaster 2.78 23 Extractum of the 0.00 present invention 24 NC 0.00 Note:PC (positive control) is 1 wt. % 2,4-Dinitrochlorobenzen NC (negativecontrol) is H₂O.

As shown in Table 7, although a part of medicinal materials in theChinese herbal medicine composition of the present invention have mildirritation, the extractum of the present invention is nonirritant.However, panchrest plaster has moderate irritant.

TEST EXAMPLE 2

Preferable extraction condition for the medicinal materials in theChinese herbal medicine composition formula of the present invention

Thirteen kinds of medicinal materials in the Chinese herbal medicinecomposition formula in the present invention are mixted at equalproportion or various proportion, and extracted and condensed atdifferent conditions (temperature, organic solvent), then detected byhigh performance liquid chromatography (HPLC) after proper dilution, andthe content of indicative ingredients (Paeonia Lactiflora, RadixAngelicae Sinensis, Cortex Cinnamomi, Glycyrrhizae, Radix Et RhizomaRhei, Radix Angelicae Formosanae, Radix Angelicae Pubescentis, RhizomaNotopterygii) is calculated respectively, by comparing the extractionresults of medicinal materials under different conditions, the optimalmedicinal materials extraction condition is optimized. The result isshown in Table 8.

TABLE 8 Different extraction condition for 13 kinds of medicinalmaterials in the Chinese herbal medicine composition formula in thepresent invention Ratio between medicinal materials and filtrating No.Filtrating solition Temperature solution Extracting time PN-1 95 wt %ethanol 80° C. (boiling) 1:8 Three hours for twice PN-2 75 wt % ethanol80° C. (boiling) 1:8 Three hours for twice PN-3 50 wt % ethanol 80° C.(boiling) 1:8 Three hours for twice PN-4 25 wt % ethanol 80° C.(boiling) 1:8 Three hours for twice PN-5  0 wt % ethanol 80° C.(boiling) 1:8 Three hours for twice PN-7 95 wt % ethanol 50° C. 1:8Three hours for twice PN-8 95 wt % ethanol  0° C. 1:8 Three hours fortwice

The average content of the indicative ingredients by milligram in 1 g ofthe extracting solution of medicinal materials by HPLC under differentconditions (n=3), the result is shown in Table 9. As can be seen fromTable 9, the 95 wt % to 50 wt % of ethanol or higher temperature isused; more indicative ingredients can be achieved by extracting.

TABLE 9 Ferulic Imperatorin Osthol or No. Paeoniflorin acidCinnamaldehyde Glycyrrhizin Rhein or isopsoralen osthole IsoimperatorinGingerol PN-1 2.97792 0.25490 1.43932 6.45148 0.67543 0.48444 0.926210.47271 0.28772 PN-2 2.29726 0.20914 1.07004 4.06984 0.48820 0.366410.66010 0.37264 0.27733 PN-3 2.26606 0.23524 0.47223 4.63019 0.432970.29041 0.64084 0.28347 0.27321 PN-4 1.89943 0.18855 0.08628 3.793550.35678 0.07382 0.19051 0.06720 0.24432 PN-5 2.04702 0.16077 0.000001.97975 0.19599 0.00000 0.02403 0.01587 0.13765 PN-7 1.95302 0.098671.32801 2.35790 0.39206 0.39484 0.58352 0.36948 0.23519 PN-8 1.631570.07588 1.29591 1.17364 0.21043 0.32561 0.70000 0.32067 0.17769

TEST EXAMPLE 3

HPLC chromatograms for each kind of medicinal materials in the Chineseherbal medicine composition formula in the present invention.

1 g of each kind of medicinal materials is respectively put into anextractor with 8 g of 95 wt % ethanol, and extracted for 3 h at 80° C.,the extraction is repeated twice, and two parts of extracting solutionare collected, then filterd separately, the obtained filtrate iscondensed into extractum by a reduced pressure concentraor, and thenquantified to 150.0 mL by adding methanol (MeOH) as test solution. Thehigh performance liquid chromatography analysis is performed byinjecting 10 μL of the test solution, and then the fingerprints as shownin FIGS. 6A to 6L are established.

Wherein, FIG. 6A is the HPLC fingerprint of Radix Paeoniae Rubra and theindicative ingredient is Paeoniflorin;

FIG. 6B is the HPLC fingerprint of Radix Paeoniae Sinensis and theindicative ingredient is Ferulic acid;

FIG. 6C is the HPLC fingerprint of Cortex Cinnamon and the indicativeingredient is Cinnamaldehyde;

FIG. 6D is the HPLC fingerprint of Glycyrrhiza and the indicativeingredient is Glycyrrhizin;

FIG. 6E is the HPLC fingerprint of Radix Et Rhizoma Rhei and theindicative ingredient is Rhein;

FIG. 6F is the HPLC fingerprint of Radix Angelicae Formosanae and theindicative ingredient is Imperatorin or Isopsoralen;

FIG. 6G is the HPLC fingerprint of Radix Angelicae Pubescentis and theindicative ingredient is Osthol or Osthole;

FIG. 6H is the HPLC fingerprint of Rhizoma Notopterygii and theindicative ingredient is Isoimperatorin;

FIG. 6I is the HPLC fingerprint of Rhizoma Zingiberis;

FIG. 6J is the HPLC fingerprint of Rhizoma Bletillae;

FIG. 6K is the HPLC fingerprint of Olibanum;

FIG. 6L is the HPLC fingerprint of Radix Linderae.

TEST EXAMPLE 4

HPLC chromatograms for the Chinese herbal medicine composition formulain the present invention

1 g of each kind of medicinal materials in the Chinese herbal medicinecomposition formula of the present invention is mixed each other and toobtain 13 g mixture, the mixture is added into an extractor with 104 gof 95wt % ethanol, then extracted for 3 h at 80° C., and filterd and thefiltrate is achieved, the resulted residue is treated by theabove-mentioned procedure again, two parts of extracting solution arecollected and filterd, and the filtrate is condensed into an extractumby a reduced pressure concentrator, and then quantified into 150.0 mL byadding methanol (MeOH) as test solution. The high performance liquidchromatography analysis is performed by injecting 10 μL of the testsolution, and then the fingerprints as shown in FIG. 7 are established.

TEST EXAMPLE 5

Percutaneous experiment of the medicine materials ingredient accordingto the present invention

Test animals are Wistar rats (weight was about 250 g). During the test,test animals can eat and drink water freely. Test sample is theextractum from the Chinese herbal medicine. Rats are killed by breakingthe cervical vertebrae, and are shaved off the belly hair with electricshaver, then the belly skin is removed. The removed skin, inner of whichis moisted by normal saline, is clamped between the Donor cell andReceptor cell of Transdermal Franz Cell System. The test sample isdissolved in proper solvent, then placed in the Donor cell. Receptorcell is full of normal saline (containing 20 wt % of polyethylene glycol400). The percutaneous experiment is carried at a constant temperatureof 37° C. and at a fixed stiring speed of 500 rpm, ans is sampled at atime of 3 h, 6 h, 12 h, 24 h, 36 h and 72 h. The sample is injected intothe high performance liquid chromatograph spectrometer to analyze thecontent according to the indicative ingredients of the Chinese herbalmedicine patch.

The result is that, percutaneous ingredients that can be detected byHPLC is the following medicinal materials ingredients such as RadixAngelicae Sinensis, Paeonia Lactiflora and Cortex Cinnamomi and so on,which contains the above three indicative ingredients. The HPLCfingerprint is shown in FIG. 8.

TEST EXAMPLE 6

Analgesic experiment of the Chinese herbal medicine patch in the presentinvention

(1) Mice Acetic Acid Writhing Test Method

Principle: if the animals are stimulated by chemical substances, forexample, apply acetic acid, bradykinin or K⁺ etc. by intraperitonealinjection to stimulate peritoneum or contact skin, in order to inducepain reaction in the chemical sensitivity acceptor, and show writhingbehaviors such as abdomen shrinkage invagination, hind limb extension,body torsion or worming and so on.

Test animals are ICR mice (male, 6-8 weeks). During the experiment, testanimals can eat and drink freely. Before the experiment, animals shouldfast for 24 h. Experiment is divided into three groups, which arerespectively negative control group (patch containing no medicine),positive control group (commercial Indomethacin or Diclofenac sodiumpatch) and experiment group (using 4 different dosages of patch for theexperiment), 12 mice in each group.

The mice are weighed and made numbers, then fixed the limbs to the flatplate and shaved off the belly hair. The patch (2 cm×3 cm) is adhered tothe belly of mice for 3 h, then removed off (or do not remove thepatch). The mice are injected with 0.6 wt % of acetic acid byintraperitoneal injection. The writhing time of mice is observed in 10minutes and recorded the average value of writhing, the result is shownin FIG. 9.

The result is that, the average value of writhing for the Chinese herbalmedicine patch in the present invention is lower than that of thenegative control group (patch containing no medicine); therefore, theChinese herbal medicine patch in the present invention definitely hasanalgesic effect.

(2) Formalin Test Method

Principle: pain raction of central and peripheral nervous system can beobserved in the rats and house mice applied with diluted formalin bysubcutaneous injection, and Formalin licking feet experiment is set upearly in 1977 by Dubuisson and Dennis, the experiment is a kind ofeffective and reliable model for the selection of most of analgesicdrugs. If people is applied with formalin by subcutaneous injection,formalin can cause strong and acute burning sensation after 4-5 minutes,in the following 30-60 minutes, continuous pain occurs. If house miceare applied with formalin, they may lick their feet or stamp their feetbecause feet is stimulated by formalin to produce pain, the licking feettime taken by initial pain caused by the injected formalin in 0-5minutes is called early stage, pain reaction is mainly caused bysubstance P and bradykinin released through directly irritating painreaction acceptor. The licking feet time consumed in 15-40 minutes iscalled later stage, which is mainly caused by some chemical transmitterssuch as histamine, serotonin, prostaglandin and kinin etc., releasedfrom the damaged cells due to inflammatory reaction. In all, lickingfeet behavior caused by pain of white mice induced by formalin, canevaluate effectively activity and mechanism of analgesic treatinginflammatory and noninflammatory pain. Additionally, pain reactioncaused by formalin, concentration of which is an important factor. Whenthe concentration of formalin is in the range of 0.02-0.2 wt %, it canonly induce licking feet reaction in early stage, identified by opticalmicroscope, and the change is slight, when the concentration of formalinis 1 wt % or more, it can induce licking feet reaction in early stageand later stage, when the concentration of formalin is 5 wt %, acuteinflammatory reaction, damage and swelling of granulocytes can be seenfrom histological identification after 30 minutes.

Test animals are ICR white mice (male, 6-8 weeks). During theexperiment, test animals can eat and drink freely. Before theexperiment, animals should fast for 24 h. Experiment is divided intothree groups, which are respectively negative control group (patchcontaining no medicine), positive control group (commercial Indomethacinor Diclofenac sodium patch) and experiment group (using 4 differentdosages of patch for the experiment), 12 mice in each group.

The white mice are weighed and made numbers. The patch (2 cm×3 cm) iscut into four equal parts, then adhered to the instep of mice, and thenfixed with breathable tape. The patch is removed after 3 h, and the miceare applied with 20 μL of 1 wt % freshly formalin solution on instep bysubcutaneous injection. The licking feet time during 0-5 minutes and15-40 minutes is calculated, and the result is shown in FIG. 10.

The result is that, licking feet time for the Chinese herbal medicinepatch in the present invention is lower than that of the negativecontrol group (patch containing no medicine); therefore, the Chineseherbal medicine patch in the present invention definitely has analgesiceffect.

TEST EXAMPLE 7

Antiinflammation and detumescence test on the Chinese herbal medicinepatch in the present invention

Principle: edema caused by injecting γ-carrageenin into plantar is abiphasic effect, after injected with γ-carrageenin, different substancescan be released to induce inflammation and swelling in different timeperiod, that is to say, histamine, serotonin and platelet activatingfactor (PAF) can be released in the time period of 0-1.5 h or 20 minutesto 1 h (the first stage), and kinin can be released in the time periodof 1.5-2.5 h (the second stage), then prostaglandin and leukotriene canbe released after 2.5 h (the third stage), leading to inflammation andswelling.

Test animals are SD white rats (male, 6-8 weeks). During the experiment,test animals can eat and drink freely. Before the experiment, animalsshould fast for 24 h. Experiment is divided into three groups, which arerespectively negative control group (patch containing no medicine),positive control group (commercial Indomethacin or Diclofenac sodiumpatch) and experiment group (using 4 different dosages of patch for theexperiment), 8 rats in each group.

The white rats are weighed and made numbers, drawn a measuring line onthe plantar of white rats with sighning pen. The volume of the plantaris firstly measured by a swelling tester. The white rats are dresseswith corset elastic bandage to avoid the Chinese herbal medicine patchbited by the white rats. of the white rats in each group are appliedwith 0.1 mL of Carrageenan (10 mg/mL in saline) by subcutaneousinjection in plantar. The Chinese herbal medicine patch (2 cm×3 cm) areadhered to the plantar for positive control group and experiment group,and fixed with breathable tape, swelling percent is measured in the timeof 0 h, 2 h, 4 h, 6 h and 24 h with a swelling tester (changing theChinese herbal medicine patch after determining in different time).Observing the swelling condition in different time and draw swellingcurve of experiment group and comparison group, identifying if it is ofbiometrical differences, as shown in FIG. 11.

The result is that, swelling percent for the Chinese herbal medicinepatch in the present invention is lower than negative control group(patch containing no medicine); therefore, the Chinese herbal medicinepatch in the present invention definitely has antiinflammation anddetumescence effect.

Although the present invention has described the above examples, theseexamples do not use to define the present invention, a person skill inthe art with common knowledge of this field can make various changes andmodification without departing from the spirit of the present invention.Thus, the protection scope of the present invention should be thatdefined by the claims.

1.-73. (canceled)
 74. A Chinese herbal medicine composition comprising:a first type of medicinal materials selected from the group consistingof Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae,Radix Angelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii,Radix Linderae, Glycyrrhizae, Radix Angelicae Pubescentis, and Radix EtRhizoma Rhei; a second type of medicinal materials selected from thegroup consisting of Zingiber Officinale, Olibanum and Myrrha.
 75. TheChinese herbal medicine composition according to claim 74, wherein thesecond type of medicinal materials is one selected from the groupconsisting of Zingiber Officinale, Olibanum and Myrrha, the Chineseherbal medicine composition contains 11 kinds of medicinal materials,percent by weight of each medicinal material is in the range of9.09%±5%.
 76. The Chinese herbal medicine composition according to claim74, wherein the second type of medicinal materials is two selected fromthe group consisting of Zingiber Officinale, Olibanum and Myrrha, theChinese herbal medicine composition contains 12 kinds of medicinalmaterials, percent by weight of each medicinal material is in the rangeof 8.33%±5%.
 77. The Chinese herbal medicine composition according toclaim 74, wherein the second type of medicinal materials is threeselected from the group consisting of Zingiber Officinale, Olibanum andMyrrha, the Chinese herbal medicine composition contains 13 kinds ofmedicinal materials, percent by weight of each medicinal material is inthe range of 7.69%±5%.
 78. A method for preparing a Chinese herbalmedicine exactive comprising the following steps: providing a first typeof medicinal materials and a second type of medicinal materials, whereinthe first type of medicinal materials include Rhizoma Bletillae, CortexCinnamomi, Radix Angelicae Formosanae, Radix Angelicae Sinensis, PaeoniaLactiflora, Rhizoma Notopterygii, Radix Linderae, Glycyrrhizae, RadixAngelicae Pubescentis, and Radix Et Rhizoma Rhei, which are basicmedicinal materials, and the second type of medicinal materials is one,two or three selected from the group cosisting of Zingiber Officinale,Olibanum and Myrrha, which are added medicinal materials; adding thefirst type of medicinal materials and the second type of medicinalmaterials into the container with organic solvent, making the percent byweight of the first type of medicinal materials and second type ofmedicinal materials with the organic solvent reach 1:N, so as to form afirst mixed solution, N is a number between 3 and 12; heating the firstmixed solution to a first predetermined temperature and performing theextraction for a first predetermined time, so as to carry out firstextraction; and filtering the first mixed solution while hot, to achievefiltrate from the first extraction.
 79. The method according to claim78, further comprising the step of: condensing the filtrate from thefirst extraction into a extratum with a water content of 10-40% byweight and a content of the organic solvent of 3-30% by weight.
 80. Themethod according to claim 79, wherein the water content is 10-20% byweight, the content of the organic solvent is 5-10% by weight.
 81. Themethod according to claim 80, further comprising the following steps:reserving residue from the first extraction; adding the organic solventagain, making the percent by weight of the medicinal materials with theorganic solvent be 1:N, so as to form second mixed solution, N is anumber between 3 and 12; heating the second mixed solution to a secondpredetermined temperature and performing second extraction for a secondpredetermined time, so as to carry out second extraction; and filteringthe second mixed solution while hot, to achieve filtrate of the secondextraction.
 82. The method according to claim 81, further comprising thefollowing steps: mixing the filtrate of the first extraction and thefiltrate of the second extraction, and condensing the mixed filtrateinto a extractum with a water content of 10-40% by weight and a contentof the organic solvent of 3-30% by weight.
 83. A preparation method ofChinese herbal medicine exactive comprising the following steps:providing first type of medicinal materials and second type of medicinalmaterials, wherein the first type of medicinal materials include RhizomaBletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, Radix AngelicaeSinensis, Paeonia Lactiflora, Rhizoma Notopterygii, Radix Linderae,Glycyrrhizae, Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei,which are basic medicinal materials; the second type of medicinalmaterials is one or two or three selected from the group cosisting ofZingiber Officinale, Olibanum and Myrrha, which are added medicinalmaterials; adding the first type of medicinal materials and the secondtype of medicinal materials into a container with organic solvent,making the percent by weight of the Chinese herbal medicine compositionand the organic solvent be 1:N, so as to form first mixed solution, N isa munber between 3 and 12; heating the first mixed solution to a firstpredetermined temperature and performing extraction for a firstpredetermined time, so as to carry out first extraction; and filteringthe first mixed solution while hot, to achieve filtrate of the firstextraction.
 84. The preparation method according to claim 83, whereinthe first predetermined temperature is between 30° C. and 100° C. 85.The preparation method according to claim 84, wherein the firstpredetermined temperature is within the range of boiling point of theorganic solvent ±5° C.
 86. The preparation method according to claim 85,wherein if the organic solvent is ethanol, the first predeterminedtemperature is within the range of boiling point of ethanol ±5° C. 87.The preparation method according to claim 83, wherein the firstpredetermined time is between 1 h and 6 h.
 88. The preparation methodaccording to claim 83, further comprising the following steps:condensing the filtrate from the first extraction into an extractum witha water content of 10-40% by weight and a content of the organic solventof 3-30% by weight.
 89. The preparation method according to claim 88,wherein the water content is 10-20% by weight, the content of theorganic solvent is 5-10% by weight.
 90. The preparation method accordingto claim 83, wherein the preparation method further comprises thefollowing steops: reserving residue from the first extraction; addingthe organic solvent again, making the percent by weight of the medicinalmaterials with the organic solvent be 1:N, so as to form second mixedsolution, N is a number between 3 and 12; heating the second mixedsolution to a second predetermined temperature and performing secondextraction for a second predetermined time, so as to carry out secondextraction; and filtering the second mixed solution while hot, toachieve filtrate of the second extraction.
 91. The preparation methodaccording to claim 90, wherein boiling point of the organic solvent isT° C., the second predetermined temperature is between 30° C. and 100°C.
 92. The preparation method according to claim 90, wherein the secondpredetermined temperature is within the range of boiling point of theorganic solvent ±5° C.
 93. The preparation method according to claim 92,wherein if the organic solvent is ethanol, the second predeterminedtemperature is within the range of boiling point of ethanol ±5° C.